涩里番

In 1817, a British physician named James Parkinson published , describing for the first time cases of a neurodegenerative disorder now known as Parkinson’s disease. Today, Parkinson’s disease is the in the U.S. It affects about 1 million Americans and more than 10 million people worldwide.

The signature shaking in patients with the disease is the result of . To date, there are no treatments available that can stop or slow down the death of those cells.

We are . For over a decade, has been investigating the role that mitochondria – the powerhouses that fuel cells – play in Parkinson’s.

Our research has that could lead to new treatments for Parkinson’s disease and other brain conditions.

Mitochondrial dynamics and neurodegeneration

Unlike actual power plants, which are set in size and location, mitochondria are rather dynamic. They constantly shift in size, number and location, traveling between many different parts of the cells to meet different demands. These are vital to not only the function of mitochondria but also the health of cells overall.

A cell is like a factory. Multiple departments must seamlessly work together for smooth operations. Because many major processes interconnect, impaired mitochondrial dynamics could cause a domino effect across departments and vice versa. in different parts of the cell eventually leads to cell death.

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Mitochondria produce the energy that fuels cells.

Emerging studies have linked imbalances in mitochondrial processes , including . In many neurodegenerative disorders, certain disease-related factors, such as toxic proteins and environmental neurotoxins, disrupt the harmony of mitochondrial fusion and division.

Impaired mitochondrial dynamics also take down the cell’s , leading to a pileup of toxic proteins that form harmful aggregates inside the cell. In Parkinson’s, the presence of these toxic protein aggregates is a .

Targeting mitochondria to treat Parkinson’s

Our team hypothesized that restoring mitochondrial function by manipulating its own dynamics could protect against neuronal dysfunction and cell death.

In an effort to restore mitochondrial function in Parkinson’s, we targeted a key protein that controls mitochondrial dynamics called . Naturally abundant in cells, this protein travels to mitochondria when they divide into smaller sizes for higher mobility and quality control. However, too much Drp1 activity causes excessive division, leading to fragmented mitochondria with impaired function.

Using different lab models of Parkinson’s, models, we found that the presence of environmental toxins and toxic proteins linked to Parkinson’s cause mitochondria to become fragmented and dysfunctional. Their presence also coincided with the buildup of those same toxic proteins, worsening the health of neuronal cells until they eventually started dying.

We also observed behavior changes in rats that impaired their movements. By reducing the activity of Drp1, however, we were able to to their normal activity and function. Their neurons were protected from disease and able to continue functioning.

Restoring mitochondrial function may be one approach to treating neurodegenerative diseases.

In our 2024 study, we found an of targeting Drp1.

We exposed neuronal cells to linked to neurodegeneration and an increased risk of parkinsonism. Surprisingly, we found that manganese was more than to its mitochondria, causing buildup of toxic proteins before mitochondria became dysfunctional. Inhibiting Drp1, however, coaxed the waste recycling system back into action, cleaning up toxic proteins despite the presence of manganese.

Our findings indicate that inhibiting Drp1 from more than one pathway could protect cells from degeneration. Now, we’ve identified some FDA-approved compounds that target Drp1 and are testing them as potential treatments for Parkinson’s.

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